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The rationale was based on the fact that humoral factors, such as immunoglobulins or circulating immune complexes, can accumulate in the plasma in rheumatic diseases.
It was hypothesized that the removal of these factors by PP/PE would correct the clinical abnormality.
On the other hand, CIDP is a chronic disease, and PP/PE or IVIG is often needed on a chronic basis.
Physicians titrate the frequency of therapies to the recurrence of symptomatology.
Hughes et al (2007) reported on a systematic evidence review of immunotherapy for GBS.In this assessment PP/PE will be used to describe the combined procedure.Therapeutic plasmapheresis (also known as platepheresis or plasma exchange) is performed to remove toxic elements from the bloodstream.In 2 studies (n = 140) the addition of PP/PE was not shown to benefit disease activity, the relapse rate, or the number of deaths in patients with polyarteritis nodosa and Churg-Strauss syndrome.In 7 studies (n = 268), therapeutic PP/PE has not been found to have an additive benefit in SLE patients with active disease or renal disease.